Acamprosate for alcohol dependence

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Acamprosate for alcohol dependence.

BACKGROUND Alcohol dependence is among the main leading health risk factors in most developed and developing countries. Therapeutic success of psychosocial programs for relapse prevention is moderate, but could potentially be increased by an adjuvant treatment with the glutamate antagonist acamprosate. OBJECTIVES To determine the effectiveness and tolerability of acamprosate in comparison to ...

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Acamprosate: a new tool in the battle against alcohol dependence

Acamprosate, a medication that has been used in Europe for years, is the newest drug to be approved by the US Federal Drug Administration for the treatment of alcohol dependence. It has been shown to assist in the maintenance of abstinence in recently detoxified alcohol-dependent individuals. The following review delineates the proposed mechanism of action and pharmacokinetics of the drug. Find...

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Safety and Efficacy of Acamprosate for the Treatment of Alcohol Dependence

Acamprosate (calcium acetylhomotaurine) is an amino acid modulator that has displayed efficacy in some clinical trials in reducing craving and promoting abstinence in alcohol dependent patients following detoxification. While acamprosate is safe and generally well-tolerated, not all studies have demonstrated clinical efficacy that is superior to placebo. In addition, the precise neurochemical m...

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Acamprosate and naltrexone, individually or in combination, for the treatment of alcohol dependence

The findings of the COMBINE Study have recently been published (Anton et al 2006). The COMBINE Study is a major, multisite RCT of acamprosate and naltrexone in conjunction with behavioural treatment. As such this study has the potential to significantly influence treatment of alcohol dependence. This brief critical appraisal of the COMBINE Study has been prepared to assess its implications in t...

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Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility

Acamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence. The exact mechanism of action of acamprosate is still under investigation, but the drug appears to work by promoting a balance between the excitatory and inhibitory neurotransmitters, glutamate and gamma-ami...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2010

ISSN: 1465-1858

DOI: 10.1002/14651858.cd004332.pub2